Cardiogen Analysis

CARDIOGEN analyses 125 polymorphisms, of which 114 are associated with classic cardio-vascular risk and 11 are independent of those risks. It has been determined that there is a direct and linear relationship between the number of genetic results (alleles) of risk and the number of cardiovascular events, so that the more risk alleles there are the greater the cardiovascular risk.

The CardioGen genetic profile integrates the genetic information with the clinical information and that on the lifestyle of the patient, and determines:

• The real cardiovascular risk, on the basis of the genetic risk factor and the relative risk, determining the cardiovascular age of the patient.
• The genetic predisposition to develop classic risk factors:
  •  Dyslipidemias: cLDL, cHDL, triglycerides
  • Arterial blood pressure
  • Diabetes mellitus
  • Obesity
  • Thrombosis
  • Nicotine dependence

CARDIOGEN is especially aimed at:

• Persons with moderate cardiovascular risk
• Persons with family histories of cardiovascular illness
• Persons of over 35 years of age classified as at low risk and without family histories.

The CardioScore genetic profile makes it possible to re-classify patients as having low or moderate cardiovascular risk, by determining the real cardiovascular risk.

The analysis consists of the evaluation of 11 genetic polymorphisms independently of the classic cardiovascular risk factors. It has been established that there is a direct and linear relationship between the number of genetic results (alleles) of risk and the number of cardiovascular events, so that the more alleles the greater the risk.

The CardioScore genetic profile makes it possible to reclassify 7% of low-risk patients, 15% of moderate-risk patients and 23% of high risk patients to a higher risk category. This means that in the case of one in every four patients with high cardiovascular risk and one in six with moderate risk, according to the habitual risk functions, it is necessary to apply stricter therapeutic objectives in reality.

CardioScore integrates the genetic information with the clinical information and information on lifestyle of the patient to determine the real cardiovascular risk. The analysis evaluates:

• Global cardiovascular risk (classical and genetic risk factors)
• Genetic risk factor
• Relative risk
• Cardiovascular age of the patient

Indications:

• The CardioScore genetic profile is indicated for:
• Patients under treatment (high cardiovascular risk)
• Patients with moderate cardiovascular risk
• Patients with low cardiovascular risk.

A profile which measures the fatty acids in the serum. It reflects the fatty acids circulating which come from the triglycerides and are mainly a reflection of the fatty acids in the diet. This technique is recommended therefore in profiles of nutrition in the absence of any pathology.

According to the composition of fatty acids, there may be an influence on levels of cholesterol HDL and LDL.

FATTY ACID profile ω3, ω6 in erythrocytes (AGRE)

In this test, instead of analysing the fatty acids in the serum, this is done in membranes of erythrocytes. The membranes of the majority of cells have a very similar composition of fatty acids and to be exact those of the membranes of the erythrocytes are very similar to those of the membranes of cerebral cells. 

The composition in fatty acids of the cellular membranes is very closely related with the illness. If there is little fluidity (predominance of AG saturates), this is associated with pathologies such as insulin resistance, lower functionality of red blood corpuscles with greater difficulty of circulation through the capillaries and reduction in their average lifetime. On the other hand, depending on their composition between Ω6 and Ω3 (low levels of Ω3) this is associated with inflammatory pathologies. 

As has already been mentioned, the composition has an influence on the values of LDL and HDL cholesterol.  

The analysis reflects the consumption of fatty acids over the last three months, while the fatty acid profile in serum is indicative of the ingestion of fats over the last 7-10 days.   

The report of results of each analytical profile is accompanied by personalised advice, with nutritional recommendations.