Metabolism of oestrogens

The way in which oestrogens are metabolised plays a significant role in the pathogenesis of a wide variety of conditions which depend on this. There are two ways in the metabolism of oestrogens: The dominant route, in which oestrogen is metabolised to 2-hydroxyestrone and 2-hydroxyestradiol (2OHE) called “good oestrogens”, because they do not favour or stimulate cell division in certain tissues and therefore do not promote the proliferation of cells in the breast and endometrium, a process linked to damage in the DNA and the growth of tumours, at the same time as the 2OHE when joined to the oestrogen receptors can have a blocking action for other metabolites among the more powerful oestrogens from joining the receptors within the cells.

Another metabolisation route is in 16α-hydroxyestrone (16α-OH-E1). This metabolite is more active and powerful. It joins some special receptors which may accelerate the ratio of DNA synthesis and of cell multiplication. In this regard, high levels of 16α-OH-E1 may increase the risk in illnesses that are dependent upon oestrogens such as lupus and breast cancer. Levels of 2OH-E and 16α-OH-E1, as well as the balance between them, supplies significant clinical information on the metabolism of oestrogens. If a woman has normal levels of oestrogens but her 2/16 ratio is low, indicating a dominium of the active metabolite, she may then have a greater risk of the conditions that are linked with an excess of oestrogens.

Alternatively, if her 2/16 ratio is high, her body may lack the oestrogen fuel necessary to maintain the blood tissue and therefore increase her risk of osteoporosis. The 2/16 ratio is very useful to monitor therapies designed to optimise the metabolism of oestrogens. Certain studies indicate that the balance between these two oestrogens may modulate a large variety of interventions of a dietetic nature, of nutritional supplements or lifestyles. Certain substances such as lignanes in plants (flax seeds, grains, pulses) Indole-3-carbinol (crucifers), Omega-3 fatty acids (oily fish), and Isoflavones (soya) increase the 2/16 OHE ratio. Obesity, hypo-thyroidism, pesticides, cimetidine… favour an increase in 16α -OH-E1. The levels of these oestrogens do not undergo any circadian variation. They can be measured in an isolated urine sample.

NECESSARY SAMPLE:

10 ml. of urine when you get up in the morning

TRANSPORT CONDITIONS:

Send refrigerated and keep frozen